Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative design.

BACKGROUND: Major depressive disorder (MDD) is a debilitating health condition that has significant morbidity and mortality rates. Depression can be caused due to social, biological, environmental, psychological, and genetic factors. A few biological processes have been proposed as the pathophysiological pathways of depression. Neurotrophic factors and inflammatory cytokines have been linked to depression. Thus, we aimed to investigate the serum interleukin-33 (IL-33) and mesencephalic astrocyte-derived neurotrophic factor (MANF) in MDD patients and corresponding healthy controls (HCs). METHOD: This study involved the inclusion of 129 MDD patients and 125 HCs matched by sex and age. A psychiatrist evaluated the study participants following DSM-5 criteria. The severity of the illness was assessed utilizing the Hamilton Depression Rating Scale (Ham-D). The serum concentrations of IL-33 and MANF were measured using enzyme-linked immunosorbent assay (ELISA) kits. RESULTS: The mean serum levels of IL-33 were decreased (159.12 ± 6.07 pg/ml vs. 180.60 ± 8.64 pg/ml, p = 0.042), and the MANF levels were increased (5.40 ± 0.19 ng/ml vs. 4.46 ± 0.21 ng/ml, p = 0.001) in MDD patients when compared to HCs. CONCLUSIONS: The current study proposes that lower IL-33 and higher MANF serum levels are associated with MDD progression and depression severity. These biomarkers could be used as risk assessment tools for MDD. We recommend more investigation, including a significant population, to determine the precise function of IL-33 and MANF in depression.

Monkeypox and sex: Sexual orientations and encounters are key factors to consider.

Background and Aims: The monkeypox (mpox) virus was endemic to some African countries that have recently spread worldwide creating multicountry outbreaks outside of Africa. This most current mpox outbreak is caused by a variety of factors. However, there are some conflicting ideas and pejorative claims about this. Therefore, we conducted this narrative review to highlight the associations of mpox infection with sexual orientations and encounters and to break the misconception about mpox. Methods: To find pertinent information and data, we searched Google, Google Scholar, and PubMed. The results of the study were supported by a large number of studies that demonstrated a connection between the mpox and sexual orientation. To gather information, we read the pertinent articles. Results: According to the available documents, we have seen that there are normally two ways of monkeypox transmission. However, the LGBTQ and MSM communities are disproportionately affected by mpox infection. Numerous research have only focused on the sexual orientation of victims. According to a study, there were 54,709 laboratory-confirmed cases of mpox where the majority of these cases were in men who had sex with men and reported recent sexual activity with one or more partners. According to a study from Italy, the mpoxvirus was recently discovered in a sample of human semen from cases of confirmed mpox. However, this finding has not yet been confirmed because there is a chance that the specimen was contaminated by another means. Conclusion: The present study suggests that there might have a prominent association between epidemiology of mpox infection and sexual orientations patients. Therefore, the general public should be made aware of mpox infections by healthcare authorities. They should let the people know about the facts about mpox. Only comprehensive planning and preventive measures will be able to halt this epidemic infection's pandemic progression.